New in portfolio.

Lesional psoriasis skin explant culture.
Lesional psoriasis explant culture (up to 48hrs) can be used to evaluate the acute effect of a compound on it’s target and establish doses for later in vivo work. 

The imiquimod mouse model of psoriasis.
Compounds (different routes of administration) can be tested for their effects in this quick and well validated mouse model of psoriasis.

The combination of the acute lesional psoriasis skin explant model, the imiquimod mouse model and the chronic transplant model of psoriasis will be of interest to companies as it allows them to routinely develop and screen compounds in vitro and then in vivo at one centre, saving time and money.

Recent articles:

K Mihara et al. Br J Dermatol.
Inhibition of p38 kinase suppresses the development of psoriasis-like lesions in a human skin transplant model of psoriasis.

pubmed link for article

S.Laggie et al.
S.Laggie et al. Submitted: The tripeptide KdPT ameliorates on-going psoriasis-like skin inflammation in murine and human skin.

G.R.Elliott et al.
Poster presented at the 2012 ESDR meeting in Venice , Italy. Diurnal changes in scratch number and frequency (Hz) during a chronic oxazolone-induced inflammation in BALB/c mice.

pruritus poster ESDR 2012